If by Rt10/Rt 5 you mean I-10 & I-5, then I have a whole list of POIs because I have been on both of those Interstates from start to finish! From the Mexico border up to the Canadian border on I-5 and from Santa Monica, CA to Jacksonville, FL on I-10. There's a lot of stuff in between and we still haven't seen everything we want.
Since you aren't heading to Disneyland in Calif until after April, I hope you get there before the summer months. Southern California is mostly desert and very hot in summer and a lot of tourists forget about this. The irony is the general lack of humidity, hence you'll hear the term, "It's HOT, but it's a dry heat". That just means you'll toast or burn and want to pour water on yourself.
Some ideas on what you like to do and see and how fast you'll be going would help. The slower you go, the more you get to see. Besides the Grand Canyon there are many equally incredible natural sites to see (Big Sur, Yosemite, Crater Lake, Mts. Hood, Shasta and Raineer). And like Las Vegas or Disneyland, just as many man-made items to visit (All of San Francisco, train museum in Sacramento, and many other cities along the way). And I've only covered 3 states (California, Oregon & Washington).
Then there are countless "gems" that are fun things to say you've seen and done that many in the membership have experienced. The list will be long and I hope you get to each and every one of them!
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