I don't remember any grade being that bad on that route, towing or not. Hwy 101 is quite wide through there with lots of semitruck/trailers going through there. On steep grades I use lower gears up or down. You should be fine. In fact, it would probably be the easiest route overall compared to any other side route.
Hopefully, some one else will post quickly to confirm. It's been a few years since we've been through that area and I still think it would still be the easiest to use from Hollister to SLO.
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