Dick, we used to have a Montana with "D" load rating tires. I bought a used replacement tire that looked almost new for next to nothing at the tire place but it was an "E" load rated tire. I went ahead and put that on the axle in place of the bad tire rather than making it the spare. After a few thousand miles I stopped in Goshen to ask the factory service center to see if I have an axle alignment problem. They measured and said it's out of alignment and it is because of the different resistance of that E tire on one end of the axle and the D on the other.
So, if that can throw an axle out of alignment, my guess is you would have the same problem with two different tire sizes on an axle. I don't know that for sure but that would be my bet based on what the service manager at Keystone told me.
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