We use bleach. Pour it into the fill hose and fill your on-board water tank. Turn on all the faucets to push the mixture through all of the lines, including the drains. Let the bleach water sit over night, drain the on-board water tank, (we do it through the faucets), and then fill with fresh water.
Also, a suggestion. Use a sediment filter for all of your water going into your unit, including the on-board holding tank. We have never had any problems with sand in the screens or low water pressure from using this process.
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