The University of Michigan did an in depth study on this and proved that you get better mileage with the tail gate on - but that wasn't when towing a 5th wheel trailer. As far as I know, no one's ever done a study on what the effects are once you add a trailer. Regardless, I use the stock tailgate because after we unhook, I can roll out the tonneau cover and keep prying eyes away from the bed contents.
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