I don't know how it works for other brands but in the Fords, the F250 and F350 single rear wheel have the same frame, axle, brakes, and front suspension. The F350 has one more leaf in the rear suspension, giving it more payload capacity. Some of us add airbags to the F250 to avoid any drooping of the rear end. I am not sure whether the dually has the same frame and brakes as the single rear wheel or not.
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