Try Palisade, which is east of Grand Junction. Thats kind of the center of wine country in Colorado. The oil and gas workers have a monopoly on the campgrounds, so get reservations early.
I haven't seen you drive, so we'll have to ask you wife if SHE is concerned about driving over I-70
. It's not a treacherous road, it's just steep. Respect the hazard by making sure your gear is in good operating condition and you will do fine. It is a main artery for trucking as well as RVs, so you won't be alone.