Yes, it is not hard to accomplish. Toughest part is finding the right size socket (1 1/16") to remove the anode with.
Removing the anode is the preferred way to drain the hotwater heater as a step in winterizing the unit. You need to "inspect" annually but only replace as needed. depending on your use and the quality of the water at the various places you stay the anode should last a year AT THE MINIMUMN. It "May" last 2 or 3 years. If mine is over half gone when I check it I replace it to ensure it will not be used up before my next inspection.
WARNINGS!!!!
Make sure your hot water contents have cooled before removing the anode and that you relieved any pressure in the tank by manually opening the relief valve. You do not want to start the job and have hot water spray all over you....falls into the "Bad Day" category.
Bill