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I agree with Jeffba, I just cleaned my HW Tank and noticed the build-up on the treads. I let it be and then put the anode rod back with new plumber's tape. The threads of the anode rod did not come close to the deposits!
However, if you want to clean the threads, or soak them, then vinegar or apple cider vinegar is the way to go o clean hardwater deposits. Wont hurt the tank and it won't hurt you!
Cheers
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