[CarWin]

You should have no issues what so ever , as long as you have drained your water heater and left the anode rod/plug out of it. When you bypass the heater, then blow air thru lines, it gets any remaining water out of them.

Basically no different than running antifreeze thru the system, it will only get to where the valves allow it to go. Also don't forget to add antifreeze to all your drain lines and toilet valve as they are most likely to freeze if left untreated. Washing machine lines if so equipped.